scleroderma

from WordNet (r) 3.0 (2006)

scleroderma
    n 1: an autoimmune disease that affects the blood vessels and
         connective tissue; fibrous connective tissue is deposited
         in the skin [syn: {scleroderma}, {dermatosclerosis}]
    2: genus of poisonous fungi having hard-skinned fruiting bodies:
       false truffles [syn: {Scleroderma}, {genus Scleroderma}]

from The Collaborative International Dictionary of English v.0.48

Scleroderma \Scler`o*der"ma\, n. [NL.] (Med.)
   A disease of adults, characterized by a diffuse rigidity and
   hardness of the skin.
   [1913 Webster]