Santiago n 1: city in the northern Dominican Republic [syn: {Santiago de los Caballeros}, {Santiago}] 2: a port city in southeastern Cuba; industrial center [syn: {Santiago de Cuba}, {Santiago}] 3: the capital and largest city of Chile; located in central Chile; one of the largest cities in South America [syn: {Gran Santiago}, {Santiago}, {Santiago de Chile}, {capital of Chile}] 4: a naval battle in the Spanish-American War (1898); the United States fleet bottled up the Spanish ships in the harbor of Santiago de Cuba and destroyed them when they tried to escape [syn: {Santiago}, {Santiago de Cuba}]