Wise -- U.S. County in Virginia Population (2000): 40123 Housing Units (2000): 17792 Land area (2000): 404.042338 sq. miles (1046.464808 sq. km) Water area (2000): 1.178921 sq. miles (3.053391 sq. km) Total area (2000): 405.221259 sq. miles (1049.518199 sq. km) Located within: Virginia (VA), FIPS 51 Location: 36.953238 N, 82.623990 W Headwords: Wise Wise, VA Wise County Wise County, VA