Wayne -- U.S. County in West Virginia Population (2000): 42903 Housing Units (2000): 19107 Land area (2000): 505.792254 sq. miles (1309.995869 sq. km) Water area (2000): 6.397241 sq. miles (16.568778 sq. km) Total area (2000): 512.189495 sq. miles (1326.564647 sq. km) Located within: West Virginia (WV), FIPS 54 Location: 38.228033 N, 82.469841 W Headwords: Wayne Wayne, WV Wayne County Wayne County, WV