Tupelo, MS -- U.S. city in Mississippi Population (2000): 34211 Housing Units (2000): 14551 Land area (2000): 51.105468 sq. miles (132.362550 sq. km) Water area (2000): 0.318565 sq. miles (0.825079 sq. km) Total area (2000): 51.424033 sq. miles (133.187629 sq. km) FIPS code: 74840 Located within: Mississippi (MS), FIPS 28 Location: 34.259585 N, 88.725885 W ZIP Codes (1990): 38801 Note: some ZIP codes may be omitted esp. for suburbs. Headwords: Tupelo, MS Tupelo