Sinistrously \Sin"is*trous*ly\ (s[i^]n"[i^]s*tr[u^]s*l[y^]), adv. 1. In a sinistrous manner; perversely; wrongly; unluckily. [1913 Webster] 2. With a tendency to use the left hand. [1913 Webster] Many, in their infancy, are sinistrously disposed, and divers continue all their life left-handed. --Sir T. Browne. [1913 Webster]