Seneca, SC -- U.S. city in South Carolina Population (2000): 7652 Housing Units (2000): 3677 Land area (2000): 7.055264 sq. miles (18.273048 sq. km) Water area (2000): 0.038215 sq. miles (0.098976 sq. km) Total area (2000): 7.093479 sq. miles (18.372024 sq. km) FIPS code: 65095 Located within: South Carolina (SC), FIPS 45 Location: 34.684145 N, 82.955778 W ZIP Codes (1990): 29678 Note: some ZIP codes may be omitted esp. for suburbs. Headwords: Seneca, SC Seneca