Prentiss -- U.S. County in Mississippi Population (2000): 25556 Housing Units (2000): 10681 Land area (2000): 414.926524 sq. miles (1074.654719 sq. km) Water area (2000): 3.315734 sq. miles (8.587710 sq. km) Total area (2000): 418.242258 sq. miles (1083.242429 sq. km) Located within: Mississippi (MS), FIPS 28 Location: 34.617939 N, 88.530079 W Headwords: Prentiss Prentiss, MS Prentiss County Prentiss County, MS