Pickens -- U.S. County in South Carolina Population (2000): 110757 Housing Units (2000): 46000 Land area (2000): 496.892936 sq. miles (1286.946741 sq. km) Water area (2000): 14.958564 sq. miles (38.742501 sq. km) Total area (2000): 511.851500 sq. miles (1325.689242 sq. km) Located within: South Carolina (SC), FIPS 45 Location: 34.828839 N, 82.701497 W Headwords: Pickens Pickens, SC Pickens County Pickens County, SC