Palmetto, FL -- U.S. city in Florida Population (2000): 12571 Housing Units (2000): 5776 Land area (2000): 4.315565 sq. miles (11.177262 sq. km) Water area (2000): 0.134124 sq. miles (0.347379 sq. km) Total area (2000): 4.449689 sq. miles (11.524641 sq. km) FIPS code: 54250 Located within: Florida (FL), FIPS 12 Location: 27.522115 N, 82.578418 W ZIP Codes (1990): 34221 Note: some ZIP codes may be omitted esp. for suburbs. Headwords: Palmetto, FL Palmetto