O'Fallon, MO -- U.S. city in Missouri Population (2000): 46169 Housing Units (2000): 15920 Land area (2000): 22.467702 sq. miles (58.191079 sq. km) Water area (2000): 0.006537 sq. miles (0.016932 sq. km) Total area (2000): 22.474239 sq. miles (58.208011 sq. km) FIPS code: 54074 Located within: Missouri (MO), FIPS 29 Location: 38.784358 N, 90.708004 W ZIP Codes (1990): Note: some ZIP codes may be omitted esp. for suburbs. Headwords: O'Fallon, MO O'Fallon