Isola, MS -- U.S. town in Mississippi Population (2000): 768 Housing Units (2000): 307 Land area (2000): 0.738101 sq. miles (1.911672 sq. km) Water area (2000): 0.000000 sq. miles (0.000000 sq. km) Total area (2000): 0.738101 sq. miles (1.911672 sq. km) FIPS code: 35220 Located within: Mississippi (MS), FIPS 28 Location: 33.262467 N, 90.593708 W ZIP Codes (1990): 38754 Note: some ZIP codes may be omitted esp. for suburbs. Headwords: Isola, MS Isola