Hughes -- U.S. County in South Dakota Population (2000): 16481 Housing Units (2000): 7055 Land area (2000): 740.920607 sq. miles (1918.975480 sq. km) Water area (2000): 59.373714 sq. miles (153.777208 sq. km) Total area (2000): 800.294321 sq. miles (2072.752688 sq. km) Located within: South Dakota (SD), FIPS 46 Location: 44.418527 N, 100.159269 W Headwords: Hughes Hughes, SD Hughes County Hughes County, SD