Hillsboro, MO -- U.S. city in Missouri Population (2000): 1675 Housing Units (2000): 620 Land area (2000): 2.388172 sq. miles (6.185338 sq. km) Water area (2000): 0.000000 sq. miles (0.000000 sq. km) Total area (2000): 2.388172 sq. miles (6.185338 sq. km) FIPS code: 32248 Located within: Missouri (MO), FIPS 29 Location: 38.232346 N, 90.563233 W ZIP Codes (1990): 63050 Note: some ZIP codes may be omitted esp. for suburbs. Headwords: Hillsboro, MO Hillsboro