Florence -- U.S. County in South Carolina Population (2000): 125761 Housing Units (2000): 51836 Land area (2000): 799.841914 sq. miles (2071.580958 sq. km) Water area (2000): 3.897639 sq. miles (10.094839 sq. km) Total area (2000): 803.739553 sq. miles (2081.675797 sq. km) Located within: South Carolina (SC), FIPS 45 Location: 34.065068 N, 79.740304 W Headwords: Florence Florence, SC Florence County Florence County, SC