Exacerbate \Ex*ac"er*bate\ ([e^]gz*[a^]s"[~e]r*b[=a]t; 277), v. t. [imp. & p. p. {Exacerbated} ([e^]gz*[a^]s"[~e]r*b[=a]`t[e^]d); p. pr. & vb. n. {Exacerbating} ([e^]gz*[a^]s"[~e]r*b[=a]`t[i^]ng).] [L. exacerbatus, p. p. of exacerbare; ex out (intens.) + acerbare. See {Acerbate}.] To render more violent or bitter; to irritate; to exasperate; to imbitter, as passions or disease. --Brougham. [1913 Webster]