dysphoria

from WordNet (r) 3.0 (2006)

dysphoria
    n 1: abnormal depression and discontent [ant: {euphoria},
         {euphory}]

from The Collaborative International Dictionary of English v.0.48

Dysphoria \Dys*pho"ri*a\, n. [NL., fr. Gr. ?, fr. ? hard to
   bear; dys- ill, hard + fe`rein to bear: cf. F. dysphorie.]
   (Med.)
   Impatience under affliction; morbid restlessness;
   dissatisfaction; the fidgets.
   [1913 Webster]