clostridium \clostridium\ n. {clostridia} 1. spindle-shaped bacterial cell esp. one swollen at the center by an endospore. Syn: clostridia. [WordNet 1.5] 2. [capitalized] a genus of anaerobic, spore-forming motile bacteria of the family {Bacillaceae}, including several pathogenic species, such as the causative agents of gas gangrene ({Clostridium perfringens}), botulism ({Clostridium botulinum}), and tetanus ({Clostridium tetani}). [PJC]