Cherokee -- U.S. County in South Carolina Population (2000): 52537 Housing Units (2000): 22400 Land area (2000): 392.690603 sq. miles (1017.063949 sq. km) Water area (2000): 4.591311 sq. miles (11.891440 sq. km) Total area (2000): 397.281914 sq. miles (1028.955389 sq. km) Located within: South Carolina (SC), FIPS 45 Location: 35.080291 N, 81.633920 W Headwords: Cherokee Cherokee, SC Cherokee County Cherokee County, SC