Cape Girardeau -- U.S. County in Missouri Population (2000): 68693 Housing Units (2000): 29434 Land area (2000): 578.619499 sq. miles (1498.617560 sq. km) Water area (2000): 7.669386 sq. miles (19.863617 sq. km) Total area (2000): 586.288885 sq. miles (1518.481177 sq. km) Located within: Missouri (MO), FIPS 29 Location: 37.358761 N, 89.628002 W Headwords: Cape Girardeau Cape Girardeau, MO Cape Girardeau County Cape Girardeau County, MO