Calhoun -- U.S. County in South Carolina Population (2000): 15185 Housing Units (2000): 6864 Land area (2000): 380.224825 sq. miles (984.777734 sq. km) Water area (2000): 12.110868 sq. miles (31.367003 sq. km) Total area (2000): 392.335693 sq. miles (1016.144737 sq. km) Located within: South Carolina (SC), FIPS 45 Location: 33.669366 N, 80.792771 W Headwords: Calhoun Calhoun, SC Calhoun County Calhoun County, SC