anaplerosis \an`a*ple*ro"sis\ ([a^]n`[.a]*pl[-e]*r[=o]"s[i^]s), n. 1. (Med.) A filling up; restoring a defective part; especially, promoting granulation of wounds or ulcers. [AS] 2. (Med) The process of restoring the depleted cellular metabolic intermediate pools; most commonly used to refer to the restoration of the citric acid cycle intermediates pool. [AS]