DeSoto -- U.S. County in Mississippi Population (2000): 107199 Housing Units (2000): 40795 Land area (2000): 477.862453 sq. miles (1237.658020 sq. km) Water area (2000): 18.907408 sq. miles (48.969960 sq. km) Total area (2000): 496.769861 sq. miles (1286.627980 sq. km) Located within: Mississippi (MS), FIPS 28 Location: 34.904345 N, 89.992068 W Headwords: DeSoto DeSoto, MS DeSoto County DeSoto County, MS