63501 -- U.S. ZIP code Municipality (1990): KIRKSVILLE, Missouri All ZIPs for this municipality (1990): 63501 Population (2000): 21110 Housing Units (2000): 9069 Land area (2000): 209.031433 sq. miles (541.388903 sq. km) Water area (2000): 1.349651 sq. miles (3.495580 sq. km) Total area (2000): 210.381084 sq. miles (544.884483 sq. km) Located within: Missouri (MO) Location: 40.183335 N, 92.583416 W