34221 -- U.S. ZIP code Municipality (1990): PALMETTO, Florida All ZIPs for this municipality (1990): 34221 Population (2000): 31646 Housing Units (2000): 14947 Land area (2000): 51.649912 sq. miles (133.772651 sq. km) Water area (2000): 0.521965 sq. miles (1.351884 sq. km) Total area (2000): 52.171877 sq. miles (135.124535 sq. km) Located within: Florida (FL) Location: 27.549314 N, 82.559816 W