33043 -- U.S. ZIP code Municipality (1990): BIG PINE KEY, Florida All ZIPs for this municipality (1990): 33043 Population (2000): 5159 Housing Units (2000): 3356 Land area (2000): 18.937412 sq. miles (49.047669 sq. km) Water area (2000): 0.501951 sq. miles (1.300046 sq. km) Total area (2000): 19.439363 sq. miles (50.347715 sq. km) Located within: Florida (FL) Location: 24.675731 N, 81.343595 W