21640 -- U.S. ZIP code Municipality (1990): HENDERSON, Maryland All ZIPs for this municipality (1990): 21640 Population (2000): 1388 Housing Units (2000): 562 Land area (2000): 22.420261 sq. miles (58.068207 sq. km) Water area (2000): 0.041704 sq. miles (0.108012 sq. km) Total area (2000): 22.461965 sq. miles (58.176219 sq. km) Located within: Maryland (MD) Location: 39.077330 N, 75.799926 W