bitter pill

from Moby Thesaurus II by Grady Ward, 1.0
39 Moby Thesaurus words for "bitter pill":
      acerbity, acridity, acridness, affliction, astringence,
      astringency, bitter cup, bitter draft, bitter draught, bitterness,
      burden, burden of care, cankerworm of care, care, causticity,
      cross, crown of thorns, curse, distress, encumbrance, gall,
      gall and wormwood, grievance, infliction, load, oppression,
      pack of troubles, peck of troubles, pungency, sea of troubles,
      sharpness, sorrow, sourness, tartness, thorn, trouble,
      waters of bitterness, weight, woe