Lactam \Lac"tam\, n. [Lactone + amido.] (Chem.) One of a series of anhydrides of an amido type, analogous to the lactones, as oxindol; a cyclic amide. [1913 Webster] {beta-lactam} or {[beta]-lactam}, (a) a lactam in which the amide bond is contained within a four-membered ring, which includes the amide nitrogen and the carbonyl carbon. (b) an antibiotic containing a beta-lactam, such as a {penicillin}, {cephalosporin}, or {carbapenem}; also called a {beta-lactam antibiotic}. [informal, laboratory slang] [PJC]